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The PubMed and EMBASE databases were searched systematically for randomized and nonrandomized controlled trials of EBRT used as primary treatment or in neoadjuvant, adjuvant, and salvage settings for localized PCa. The study quality and risk of bias were assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) and Oxford Quality Appraisal tools, respectively. Twenty randomized trials (n = 13,281) and 14 nonrandomized studies (n = 3,851) were included in the analysis. The methodological quality of the randomized trials was of moderate-to-low quality, with the exception of the Brachytherapy for Localized Prostate Cancer (BRiSP) trial. The majority of trials found no significant difference in efficacy outcomes (metastases-free survival, biochemical disease-free survival, freedom from adjuvant therapy, and overall survival) between EBRT and other local therapies. 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